Medical treatment of obesity Hosseinpanah
Medical treatment of obesity
F. Hosseinpanah, M.D
Obesity Research Center
Research Institute for Endocrine sciences
Shahid Beheshti University of Medical Sciences
November 29, 2019
Tehran
- Introduction
- Orlistat
- Lorcaserin
- Combination therapy
- Liraglutide
- Individualization of Pharmacotherapy
- Future Therapies
- Take home messages
Historical Roots
- Dating back to the 1890s use of sheep thyroid extract (to induce weight loss in euthyroid patients) resulted in reports of cardiac arrhythmias and death
- In 1930s, 2,4‑dinitrophenol used for weight loss caused fatal hyperthermia, agranulocytosis and the development of cataracts.
- In the 1950s, amphetamine use became popular, especially in combination with other mixed regimens such as diuretics, laxatives and thyroid hormone, but resulted in reports of serious MI and sudden deaths
